{"id":1623,"date":"2023-04-28T23:31:32","date_gmt":"2023-04-28T21:31:32","guid":{"rendered":"https:\/\/medicallib.co.za\/health-info\/?p=1623"},"modified":"2023-04-28T23:31:40","modified_gmt":"2023-04-28T21:31:40","slug":"oral-glucose-solutions-use-for-glucose-tolerance-test","status":"publish","type":"post","link":"https:\/\/medicallib.co.za\/health-info\/oral-glucose-solutions-use-for-glucose-tolerance-test\/","title":{"rendered":"Oral glucose solutions use for glucose tolerance test"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.19.5″ _module_preset=”default” custom_margin=”-65px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.19.5″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.19.5″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.21.0″ _module_preset=”default” text_text_color=”#000000″ text_font_size=”16px” text_line_height=”2em” header_2_text_color=”#0C71C3″ hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]

The glucose tolerance test (GTT), also called the oral glucose tolerance test (oGTT) is a diabetes<\/a><\/span> test used to diagnose type 2 diabetes<\/a><\/span> and gestational diabetes mellitus<\/a><\/span> (GDM). GTT can be used for both children and adults. The procedure involves the test subject drinking an oral glucose solution (OGS) after which blood will be drawn. Blood is drawn after one hour, two hours, or three hours to evaluate how their body processes glucose. However, to confirm diagnosis the test needs to be repeated using a different blood sample and on a different day. But to have a reproducible outcome and to avoid false results, strict quality criteria must be followed<\/a><\/span>.<\/p>\n

The patient\u2019s general health condition, the use of medication, diet, smoking habit, physical activity, gastric emptying, blood sample handling and preparation, and the type of oral glucose solution used will influence the reproducibility and accuracy of GTT. There are different types of OGS used in different countries. Some are freshly prepared while others are commercially available and ready-to-use. In either case, there is no universal or standard procedure for preparation and the composition usually varies. For example, the excipients added to improve taste and smell can alter blood glucose levels after drinking the OGS or influence the secretion of insulin. Also, the rate of absorption of freshly prepared OGS compared to commercially available and ready to use OGS is not known. These concerns need to be<\/a><\/span> adequately answered and addressed.<\/p>\n

Freshly prepared oral glucose solution<\/h2>\n

Pure glucose is not very soluble in water and care must be taken when dissolving it in water. The glucose should be poured slowly while constantly stirring. Other forms of glucose such are glucose monohydrate are more soluble in water, but care must be taken to include the weight of the water in the calculation. For example, 55.0 g, 82.5 g, and 110.0 g of glucose monohydrate will contain 50 g, 75 g, and 100 g of pure glucose, respectively. \u00a0Tap water is used with no additive or conservative. OGS are mostly prepared in a 50 g, 75 g, or 100 g dose in quantities between 200 to 300 mL.<\/p>\n

Although freshly prepared OGS offer the advantage of being cheaper, it comes with some disadvantages. Disadvantages of freshly prepared oral glucose solution include:<\/p>\n