Pill with M365 imprint or M365 pill is an opioid medication made up of a mixture of acetaminophen and hydrocodone. M365 is prescribed and used as a potent analgesic medication for the relief of moderate to severe pain. It comes as a 15 mm white and oblong shaped capsule with a strength of 325 mg / 5 mg (acetaminophen/hydrocodone bitartrate). Although effective in the treatment of chronic pain, back pain, cough, or discomfort and restlessness following surgery, M365 is very addictive and can result to uncomfortable withdrawal symptoms. As such, it is only available on prescription to manage pain conditions for which over-the-counter analgesics are ineffective.
Common side effects of using M365 include lightheadedness, nausea, vomiting, constipation, or drowsiness. But, severe side effects are also common with the use of M365 and include allergic reaction, respiratory distress, changes in appetite, mode changes, liver failure, or drug dependence which can result to unpleasant withdrawal symptoms. Due to its dizzying effect, M365 can also interfer with motor skills. Therefore, patients under this medication should avoid driving or using unsafe machinery.
How to correctly identify an M365 pill
The image for M365 pill is as shown. M365 is an elongated, mid-sized (15 mm), white or off-white tablet with the M365 imprint on the front. The back has a deep score in the middle to facilitate dividing the dosage.
M365 dosage, strength, and variants
M365 contains two active ingredients which are acetaminophen and hydrocodone bitartrate. Acetaminophen is a common and non-opioid pain killer and fever reducer that is sold over-the-counter. However, hydrocodone is an opioid pain killer available only on prescription. Depending on the patient’s requirement or severity of the pain being treated, there are different strengths of the acetaminophen and hydrocodone bitartrate available. Each of these comes with a different shape, color, name, or imprint as see in the examples below:
| Imprint | Strength (acetaminophen / hydrocodone bitartrate) | Color | Shape |
|---|---|---|---|
| M365 | 325 mg / 5 mg | White | Capsule/Oblong |
| M366 | 325 mg / 7.5 mg | White | Oval |
| M367 | 325 mg / 10 mg | White | Capsule/Oblong |
| M357 | 500 mg / 5 mg | White | Oval |
| M358 | 500 mg / 7.5 mg | White | Capsule/Oblong |
| M360 | 750 mg / 7.5 mg | White | Oval |
| V 36 01 | 325 mg / 10 mg | Yellow | Oval |
| 3604 V | 325 mg / 5 mg | White | Capsule/Oblong |
| V 36 05 | 325 mg / 7.5 mg | Orange | Oval |
| WATSON 349 | 500 mg / 5 mg | White | Oval |
| WATSON 387 | 750 mg / 7.5 mg | White | Oval |
| WATSON 853 | 325 mg / 10 mg | Yellow | Oval |
| WATSON 540 | 500 mg / 10 mg | Blue | Oval |
| WATSON 502 | 650 mg / 7.5 mg | Pink | Oval |
For a complete list of acetaminophen and hydrocodone bitartrate variants, click here.
M365 addiction and signs of misuse
Because of its power and potency, M365 is categorized as a Schedule II substance and is treated as a narcotic. Therefore, people easily misuse or abuse the drug resulting to physical dependence. Signs that someone is misusing or abusing M365 include:
- Pinpoint pupils
- Itching and rashes
- Flushed or warm skin
- Dry mouth
- Gastrointestinal discomfort such as diarrhea and stomach upset.
- Changes in social behavior
- Inability to function well at home, work, or school.
- Sexual dysfunction in men
- Nausea or vomiting
- Drowsiness
- Lethargy
- Dysarthria or Slurred speech
To overcome addiction from M365, do the following:
- Come to term with the situation and seek help.
- Take part in addiction recovery programs which help individuals suffering from abuse or addiction.
- Seek support from professionals, family members, or loved ones.
Withdrawal symptoms for M365 pills
Withdrawal from M365 addiction leads to very uncomfortable withdrawal symptoms which can cause the individual involved from turning back to using the drug to temporarily feel better. Therefore, it is important to adhered to strict regimen and seek guidance from professionals and help from family members or loved ones. Common symptoms from M365 withdrawal include:
- Flu-like symptoms
- Anxiety
- Muscular aches and tension
- Unexplained or unusual sweating
- Difficulty sleeping
- General irritability
M365 pill and pregnancy
M365 is a narcotic analgesic combination of acetaminophen and hydrocodone bitartrate and is not safe for use during pregnancy. Pregnant women should generally only take narcotics if the advantages of doing so exceed any possible risk.
M365 pill and alcohol or grapefruit interaction
Patients using hydrocodone formulations, like M365, should avoid using alcohol-containing drugs or alcohol itself. Combining the two can lead to additive depression of the central nervous system (CNS) and impairment of cognitive, psychomotor, and judgmental abilities. In more serious situations, there may be a risk of hypotension, respiratory depression, deep drowsiness, coma, or even death.
Also, when using hydrocodone, patients should abstain from consuming grapefruits or grapefruit juice. This raises the hydrocodone plasma concentrations, which may intensify or extend the negative effects of the medication and perhaps result in respiratory depression that can be lethal.
